does kidney transplantation with deceased or living donor affect graft survival?
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چکیده
conclusions we found acceptable short-term survival in both groups; however, living donor recipients continue to have better long-term patient and graft survival rates. results although there were no significant differences in one-year survival rates of patient and graft between study groups, three-years survival rates of patient and graft were significantly longer in living donor kidney transplants in comparison with the deceased donor kidney recipients (p = 0.006 and p = 0.004, respectively). in cox-regression model after adjusting for other confounding factors such as age, sex, diabetes mellitus, and first- or second-time transplantation, overall patient and graft survivals were also significantly shorter in deceased kidney transplantation than those who received kidney from a living donor (hr, 3.5; 95% ci, 1.2-10.4; and p = 0.02 for patient survival; and hr, 5.4; 95% ci, 1.5-19.5; and p = 0.009 for graft survival). objectives the aim of the study was to investigate the differences in survival rates between kidney transplant recipients with deceased donor and living donor. patients and methods in a retrospective cohort study, 218 patients who had undergone kidney transplantation in our institute from april 2008 to september 2010 were recruited. demographics and post-transplantation follow-up data including immunosuppression regimens, rejection episodes, and survival rates were evaluated. the patients were assigned to two groups according to the donor kidney transplantation: group i, living donor kidney transplants; and group ii, deceased donor kidney transplants. background there are growing numbers of patients with end-stage renal disease globally at an unexpected rate. today, the most serious challenge in transplantation is organ shortage; hence, using deceased donor is increasingly encouraged.
منابع مشابه
Does Kidney Transplantation With Deceased or Living Donor Affect Graft Survival?
BACKGROUND There are growing numbers of patients with end-stage renal disease globally at an unexpected rate. Today, the most serious challenge in transplantation is organ shortage; hence, using deceased donor is increasingly encouraged. OBJECTIVES The aim of the study was to investigate the differences in survival rates between kidney transplant recipients with deceased donor and living dono...
متن کاملThe Need for New Donor Stratification to Predict Graft Survival in Deceased Donor Kidney Transplantation
PURPOSE The aim of this study was to determine whether stratification of deceased donors by the United Network for Organ Sharing (UNOS) criteria negatively impacts graft survival. MATERIALS AND METHODS We retrospectively reviewed deceased donor and recipient pretransplant variables of kidney transplantations that occurred between February 1995 and December 2009. We compared clinical outcomes ...
متن کاملKidney transplantation in older adults: does age affect graft survival?
INTRODUCTION There is a paucity of data on long-term patient and graft survival in the older kidney recipients. Our aim was to evaluate the long-term outcomes of kidney transplantation in patients aged 50 years and older and compare them with outcomes in younger recipients. MATERIALS AND METHODS Forty-seven recipients aged 50 years and older and 47 recipients aged younger than 50 years were r...
متن کاملDeceased-donor characteristics and the survival benefit of kidney transplantation.
CONTEXT Transplantation using kidneys from deceased donors who meet the expanded criteria donor (ECD) definition (age > or =60 years or 50 to 59 years with at least 2 of the following: history of hypertension, serum creatinine level >1.5 mg/dL [132.6 micromol/L], and cerebrovascular cause of death) is associated with 70% higher risk of graft failure compared with non-ECD transplants. However, i...
متن کاملDeceased-donor kidney transplantation: improvement in long-term survival.
BACKGROUND Despite marked improvement in short-term renal allograft survival rates (GSR) in recent years, improvement in long-term GSR remained elusive. METHODS We analysed the kidney transplant experience at our centre accrued over four decades to evaluate how short-term and long-term GSR had changed and to identify risk factors affecting graft survival. The study included 1476 adult recipie...
متن کاملdoes living donor hyperoxia have an impact on kidney graft function after transplantation?
conclusions oxygen therapy in the case group had no significant impact on protection from dgf. results forty living kidney transplantations including 17 cases and 23 controls were performed; female gender was more prevalent in recipients (n = 16, 40%). the mean age of recipients was 36.1 ± 12.4 (18-67) years old. dgf was detected in 2 (5.95%) individuals, from whom one was in the case group and...
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عنوان ژورنال:
nephro-urology monthlyجلد ۶، شماره ۴، صفحات ۰-۰
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